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Reference: Neer EJ, et al. (1994) The ancient regulatory-protein family of WD-repeat proteins. Nature 371(6495):297-300

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Abstract

WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.

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Journal Article | Review | Review, Tutorial
Authors
Neer EJ, Schmidt CJ, Nambudripad R, Smith TF
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