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Reference: Uhlin U and Eklund H (1994) Structure of ribonucleotide reductase protein R1. Nature 370(6490):533-9

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Abstract


Ribonucleotide reductase is the only enzyme that catalyses de novo formation of deoxyribonucleotides and is thus a key enzyme in DNA synthesis. The radical-based reaction involves five cysteins. Two redox-active cysteines are located at adjacent antiparallel strands in a new type of ten-stranded alpha/beta-barrel, and two others at the carboxyl end in a flexible arm. The fifth cysteine, in a loop in the centre of the barrel, is positioned to initiate the radical reaction.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Uhlin U, Eklund H
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