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Reference: Savva R, et al. (1995) The structural basis of specific base-excision repair by uracil-DNA glycosylase. Nature 373(6514):487-93

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Abstract


The 1.75-A crystal structure of the uracil-DNA glycosylase from herpes simplex virus type-1 reveals a new fold, distantly related to dinucleotide-binding proteins. Complexes with a trideoxynucleotide, and with uracil, define the DNA-binding site and allow a detailed understanding of the exquisitely specific recognition of uracil in DNA. The overall structure suggests binding models for elongated single- and double-stranded DNA substrates. Conserved residues close to the uracil-binding site suggest a catalytic mechanism for hydrolytic base excision.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Savva R, McAuley-Hecht K, Brown T, Pearl L
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