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Reference: Maragoudakis ME (1967) Homoaconitic acid accumulation by a lysine-requiring yeast mutant. J Bacteriol 94(4):1060-5

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Abstract


Homoaconitic acid, the second intermediate of the proposed pathway for lysine biosynthesis in yeast, is accumulated in the growth medium of a lysine-requiring mutant. This acid has been identified on paper and column chromatography by comparing it with authentic cis-homoaconitic acid. The infrared spectrum of the isolated material was identical with that of synthetic cis-homoaconitic acid. In addition, the chemical structure of the enzymatic product has been verified by degradation to glyoxylic and alpha-ketoglutaric acids after treatment with KMnO(4) and HIO(4) and by catalytic reduction to the saturated acid 1,2,4-butanetricarboxylic acid. The isolated homoaconitic acid was also identified as a substrate for a purified enzyme preparation of homoaconitase.

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Journal Article
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Maragoudakis ME
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