Reference: Murray AN and Kelly JW (2012) Hsp104 gives clients the individual attention they need. Cell 151(4):695-7

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Abstract

Yeast heat shock protein 104 (Hsp104), the only known eukaryotic disaggregase, remodels both disordered protein aggregates and cross-beta sheet amyloids. To handle this diverse clientele, DeSantis et al. report that Hsp104 hexamers use distinct mechanisms-individual subunits are able to dissolve disordered aggregates, but global subunit cooperativity is required to untangle amyloids.CI - Copyright (c) 2012 Elsevier Inc. All rights reserved.

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Comment | Journal Article
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Murray AN, Kelly JW
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