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Reference: Begley TP, et al. (2012) Thiamin biosynthesis: still yielding fascinating biological chemistry. Biochem Soc Trans 40(3):555-60

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Abstract


The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase.

Reference Type
Journal Article
Authors
Begley TP, Ealick SE, McLafferty FW
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