Reference: Takahashi T, et al. (2011) Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae. J Toxicol Sci 36(6):855-7

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Abstract


To elucidate the mechanisms underlying adriamycin resistance, adriamycin resistance-related genes were explored using the budding yeast Saccharomyces cerevisiae as a useful eukaryotic model. The CLN1 and CLN2 genes, encoding G1 cyclin, and the ERG13 gene, encoding 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase, were identified.

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Journal Article
Authors
Takahashi T, Nakashima S, Masuda T, Yoneda S, Hwang GW, Naganuma A
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