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Reference: Tanizawa H and Noma KI (2012) Unravelling global genome organization by 3C-seq. Semin Cell Dev Biol 23(2):213-21

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Abstract

Eukaryotic genomes exist in the cell nucleus as an elaborate three-dimensional structure which reflects various nuclear processes such as transcription, DNA replication and repair. Next-generation sequencing (NGS) combined with chromosome conformation capture (3C), referred to as 3C-seq in this article, has recently been applied to the yeast and human genomes, revealing genome-wide views of functional associations among genes and their regulatory elements. Here, we compare the latest genomic approaches such as 3C-seq and ChIA-PET, and provide a condensed overview of how eukaryotic genomes are functionally organized in the nucleus.

Reference Type
Journal Article
Authors
Tanizawa H, Noma KI
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