Mother cell-specific ageingageing is a well-known phenomenon in budding yeast Saccharomyces cerevisiae. Asymmetric segregationsegregation of damagedamage and its accumulation in the mother cell has been proposed as one important mechanism. There are, however, unicellular organisms such as the fission yeast Schizosaccharomyces pombe, which replicates with almost no asymmetry of segregationsegregation of damagedamage and the pathogenic yeast Candida albicans, which falls around the middle of the segregationsegregation spectrum far from both complete symmetry and complete asymmetryasymmetry. The ultimate evolutionary cause that determines the way damagedamage segregates in a given organism is not known. Here we develop a mathematical model to examine the selective forces that drive the evolutionevolution of asymmetryasymmetry and discover the conditions in which symmetry is the optimal strategy. Three main processes are included in the model: protein synthesis (growth), protein damagedamage, and degradation of damagedamage. We consider, for the first time, the costs to the cell that might accompany the evolutionevolution of asymmetryasymmetry and incorporate them into the model along with known trade-offs between reproductive and maintenance investments and their energy requirements. The model provides insight into the relationship between ecology and cellular trade-off physiology in the context of unicellular ageingageing, and applications of the model may extend to multicellular organisms.
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|Evidence ID||Analyze ID||Gene||Gene Systematic Name||Gene Ontology Term||Gene Ontology Term ID||Qualifier||Aspect||Method||Evidence||Source||Assigned On||Reference||Annotation Extension|
|Evidence ID||Analyze ID||Gene||Gene Systematic Name||Phenotype||Experiment Type||Experiment Type Category||Mutant Information||Strain Background||Chemical||Details||Reference|
|Evidence ID||Analyze ID||Regulator||Regulator Systematic Name||Target||Target Systematic Name||Experiment||Conditions||Strain||Source||Reference|