Take our Survey

Reference: Rashidi A, et al. (2012) EvolutionEvolution of Asymmetric Damagedamage Segregationsegregation: A Modelling Approach. Subcell Biochem 57:315-30

Reference Help

Abstract


Mother cell-specific ageingageing is a well-known phenomenon in budding yeast Saccharomyces cerevisiae. Asymmetric segregationsegregation of damagedamage and its accumulation in the mother cell has been proposed as one important mechanism. There are, however, unicellular organisms such as the fission yeast Schizosaccharomyces pombe, which replicates with almost no asymmetry of segregationsegregation of damagedamage and the pathogenic yeast Candida albicans, which falls around the middle of the segregationsegregation spectrum far from both complete symmetry and complete asymmetryasymmetry. The ultimate evolutionary cause that determines the way damagedamage segregates in a given organism is not known. Here we develop a mathematical model to examine the selective forces that drive the evolutionevolution of asymmetryasymmetry and discover the conditions in which symmetry is the optimal strategy. Three main processes are included in the model: protein synthesis (growth), protein damagedamage, and degradation of damagedamage. We consider, for the first time, the costs to the cell that might accompany the evolutionevolution of asymmetryasymmetry and incorporate them into the model along with known trade-offs between reproductive and maintenance investments and their energy requirements. The model provides insight into the relationship between ecology and cellular trade-off physiology in the context of unicellular ageingageing, and applications of the model may extend to multicellular organisms.

Reference Type
Journal Article
Authors
Rashidi A, Kirkwood TB, Shanley DP
Primary Lit For
Additional Lit For
Review For

Interaction Annotations


Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.

Interactor Interactor Type Assay Annotation Action Modification Phenotype Source Reference

Gene Ontology Annotations


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene Gene Ontology Term Qualifier Aspect Method Evidence Source Assigned On Annotation Extension Reference

Phenotype Annotations


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

Gene Phenotype Experiment Type Mutant Information Strain Background Chemical Details Reference

Regulation Annotations


Increase the total number of rows displayed on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; to filter the table by a specific experiment type, type a keyword into the Filter box (for example, “microarray”); download this table as a .txt file using the Download button or click Analyze to further view and analyze the list of target genes using GO Term Finder, GO Slim Mapper, SPELL, or YeastMine.

Regulator Target Experiment Assay Construct Conditions Strain Background Reference