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Reference: Sharifpoor S, et al. (2011) A quantitative literature-curated gold standard for kinase-substrate pairs. Genome Biol 12(4):R39

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Abstract

We describe the Yeast Kinase Interaction Database (KID, http://www.moseslab.csb.utoronto.ca/KID/), which contains high- and low-throughput data relevant to phosphorylation events. KID includes 6,225 low-throughput and 21,990 high-throughput interactions, from greater than 35,000 experiments. By quantitatively integrating these data, we identified 517 high-confidence kinase-substrate pairs that we consider a gold standard. We show that this gold standard can be used to assess published high-throughput datasets, suggesting that it will enable similar rigorous assessments in the future.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Sharifpoor S, Nguyen Ba AN, Youn JY, Van Dyk D, Friesen H, Douglas AC, Kurat CF, Chong YT, Founk K, Moses AM, ... Show all
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Interactor Interactor Type Assay Annotation Action Modification Phenotype Source Reference

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