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Reference: Edskes HK, et al. (2011) Prion-forming ability of ure2 of yeasts is not evolutionarily conserved. Genetics 188(1):81-90

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Abstract

[URE3] is a prion (infectious protein) of the Saccharomyces cerevisiae Ure2p, a regulator of nitrogen catabolism. We show that wild S. paradoxus can be infected with a [URE3] prion, supporting the use of S. cerevisiae as a prion test bed. We find that the Ure2p of Candida albicans and C. glabrata also regulate nitrogen catabolism. Conservation of amino acid sequence within the prion domain of Ure2p has been proposed as evidence that the [URE3] prion helps its host. We show that the C. albicans Ure2p, which does not conserve this sequence, can nonetheless form a [URE3] prion, but the C. glabrata Ure2p, which does have the conserved sequence, cannot form [URE3]. These results suggest that the sequence is not conserved to preserve prion forming ability.

Reference Type
Journal Article
Authors
Edskes HK, Engel A, McCann LM, Brachmann A, Tsai HF, Wickner RB
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