Reference: Stewart JD, et al. (2010) Polymerase ? gene POLG determines the risk of sodium valproate-induced liver toxicity. Hepatology 52(5):1791-6

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Abstract


CONCLUSIONS: These findings implicate impaired liver regeneration in VPA toxicity and show that prospective genetic testing of POLG will identify individuals at high risk of this potentially fatal consequence of treatment.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Extramural
Authors
Stewart JD, Horvath R, Baruffini E, Ferrero I, Bulst S, Watkins PB, Fontana RJ, Day CP, Chinnery PF
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