Reference: Halfmann R and Lindquist S (2010) Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits. Science 330(6004):629-32

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Abstract


Prions are an unusual form of epigenetics: Their stable inheritance and complex phenotypes come about through protein folding rather than nucleic acid-associated changes. With intimate ties to protein homeostasis and a remarkable sensitivity to stress, prions are a robust mechanism that links environmental extremes with the acquisition and inheritance of new traits.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Halfmann R, Lindquist S
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