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Reference: Trcek T and Singer RH (2010) The cytoplasmic fate of an mRNP is determined cotranscriptionally: exception or rule? Genes Dev 24(17):1827-31

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Abstract


She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.

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Journal Article
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Trcek T, Singer RH
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