Reference: Noma A, et al. (2010) Expanding role of the jumonji C domain as an RNA hydroxylase. J Biol Chem 285(45):34503-7

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Abstract

JmjC (Jumonji C) domain-containing proteins are known to be an extensive family of Fe(II)/2-oxoglutarate-dependent oxygenases involved in epigenetic regulation of gene expression by catalyzing oxidative demethylation of methylated histones. We report here that a human JmjC protein named Tyw5p (TYW5) unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxywybutosine, in tRNA(Phe) by catalyzing hydroxylation. The finding provides an insight into the expanding role of JmjC protein as an RNA hydroxylase.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Noma A, Ishitani R, Kato M, Nagao A, Nureki O, Suzuki T
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