Reference: Rondon AG, et al. (2010) The interface between transcription and mRNP export: From THO to THSC/TREX-2. Biochim Biophys Acta 1799(8):533-538

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Abstract


Eukaryotic gene expression is a multilayer process covering transcription to post-translational protein modifications. As the nascent pre-mRNA emerges from the RNA polymerase II (RNAPII), it is packed in a messenger ribonucleoparticle (mRNP) whose optimal configuration is critical for the normal pre-mRNA processing and mRNA export, mRNA integrity as well as for transcription elongation efficiency. The interplay between transcription and mRNP formation feeds forward and backward and involves a number of conserved factors, from THO to THSC/TREX-2, which in addition have a unique impact on transcription-dependent genome instability. Here we review our actual knowledge of the role that these factors play at the interface between transcription and mRNA export in the model organism Saccharomyces cerevisiae.CI - Copyright (c) 2010 Elsevier B.V. All rights reserved.

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Journal Article
Authors
Rondon AG, Jimeno S, Aguilera A
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