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Reference: Cole F, et al. (2010) Evolutionary conservation of meiotic DSB proteins: more than just Spo11. Genes Dev 24(12):1201-7

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Abstract

Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) generated by the Spo11 protein. In budding yeast, five other meiotic-specific proteins are also required for DSB formation, but, with rare exception, orthologs had not been identified in other species. In this issue of Genes & Development, Kumar and colleagues (pp. 1266-1280) used a phylogenomic approach to identify two of these proteins across multiple clades, and confirmed that one of these, MEI4, is a functional ortholog in mouse.

Reference Type
Comment | Journal Article | Research Support, N.I.H., Extramural
Authors
Cole F, Keeney S, Jasin M
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