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Reference: Joshi A, et al. (2010) Characterizing regulatory path motifs in integrated networks using perturbational data. Genome Biol 11(3):R32

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Abstract


ABSTRACT: We introduce Pathicular (http://bioinformatics.psb.ugent.be/software/details/Pathicular), a Cytoscape plugin for studying the cellular response to perturbations of transcription factors by integrating perturbational expression data with transcriptional, protein-protein and phosphorylation networks. Pathicular searches for 'regulatory path motifs', short paths in the integrated physical networks which occur significantly more often than expected between transcription factors and their targets in the perturbational data. A case study in Saccharomyces cerevisiae identifies eight regulatory path motifs and demonstrates their biological significance.

Reference Type
Journal Article
Authors
Joshi A, Van Parys T, Van de Peer Y, Michoel T
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