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Reference: Lynch-Day MA and Klionsky DJ (2010) The Cvt pathway as a model for selective autophagy. FEBS Lett 584(7):1359-66

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Abstract

Autophagy is a highly conserved, ubiquitous process that is responsible for the degradation of cytosolic components in response to starvation. Autophagy is generally considered to be nonselective; however, there are selective types of autophagy that use receptor and adaptor proteins to specifically isolate a cargo. One type of selective autophagy in yeast is the cytoplasm to vacuole targeting (Cvt) pathway. The Cvt pathway is responsible for the delivery of the hydrolase aminopeptidase I to the vacuole; as such, it is the only known biosynthetic pathway that utilizes the core machinery of autophagy. Nonetheless, it serves as a model for the study of selective autophagy in other organisms.CI - Copyright (c) 2010. Published by Elsevier B.V.

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Journal Article
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Lynch-Day MA, Klionsky DJ
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