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Reference: Hughes A and Rando OJ (2009) Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC? J Biol 8(11):96

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Abstract

ABSTRACT: The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic thermodynamic preference of a given sequence in the yeast genome for the histone octamer can largely be captured with a simple model, and in fact is mostly explained by %GC. Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed.See research article http://www.biomedcentral.com/1471-2105/10/442.

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Hughes A, Rando OJ
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