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Reference: Adhikari A and Chen ZJ (2009) Diversity of polyubiquitin chains. Dev Cell 16(4):485-6

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Abstract

Polyubiquitin chains linked through different lysines of ubiquitin may exert both proteasome-dependent and -independent functions. In a recent Cell issue, Xu et al. employ quantitative proteomics to profile polyubiquitin linkages in yeast. They find that linkages through all lysines of ubiquitin, except lysine-63, can target proteasomal degradation in vivo, and that lysine-11 polyubiquitination is important for endoplasmic reticulum-associated degradation (ERAD).

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Journal Article
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Adhikari A, Chen ZJ
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