Reference: Reisman D, et al. (2009) The SWI/SNF complex and cancer. Oncogene 28(14):1653-68

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Abstract


The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).Oncogene advance online publication, 23 February 2009; doi:10.1038/onc.2009.4.

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Journal Article
Authors
Reisman D, Glaros S, Thompson EA
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