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Reference: Hao N, et al. (2008) Control of MAPK specificity by feedback phosphorylation of shared adaptor protein ste50. J Biol Chem 283(49):33798-802

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Abstract


Many different signaling pathways share common components but nevertheless invoke distinct physiological responses. In yeast, the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Whereas Kss1 activity is sustained and promotes invasive growth, Hog1 activity is transient and promotes cell adaptation to osmotic stress. Here we show that osmotic stress activates Kss1 as well as Hog1. We show further that Hog1 phosphorylates Ste50, and that phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. Thus feedback regulation of a shared component can restrict the activity of a competing MAP kinase to ensure signal fidelity.

Reference Type
Journal Article
Authors
Hao N, Zeng Y, Elston TC, Dohlman HG
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