Reference: Wickner RB, et al. (2008) Protein inheritance (prions) based on parallel in-register beta-sheet amyloid structures. Bioessays 30(10):955-64

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Abstract


Most prions (infectious proteins) are self-propagating amyloids (filamentous protein multimers), and have been found in both mammals and fungal species. The prions [URE3] and [PSI+] of yeast are disease agents of Saccharomyces cerevisiae while [Het-s] of Podospora anserina may serve a normal cellular function. The parallel in-register beta-sheet structure shown by prion amyloids makes possible a templating action at the end of filaments which explains the faithful transmission of variant differences in these molecules. This property of self-reproduction, in turn, allows these proteins to act as de facto genes, encoding heritable information.

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Journal Article | Review
Authors
Wickner RB, Shewmaker F, Kryndushkin D, Edskes HK
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