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Reference: Maxwell PH and Curcio MJ (2008) Incorporation of Y'-Ty1 cDNA Destabilizes Telomeres in Saccharomyces cerevisiae Telomerase-Negative Mutants. Genetics 179(4):2313-7

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Abstract

Ty1 retrotransposons in Saccharomyces cerevisiae are activated in response to telomere erosion. Ty1-dependent reverse transcription of mRNA from subtelomeric Y' repeats generates chimeric Y'-Ty1 cDNA. Here, we show that Y'-Ty1 cDNA is incorporated at eroding telomeres in the absence of telomerase. Telomeric incorporation of Y'-Ty1 cDNA promotes genome rearrangements.

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Journal Article
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Maxwell PH, Curcio MJ
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