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Reference: Zhang YQ and Rao R (2008) A spoke in the wheel: calcium spikes disrupt yeast cell cycle. Cell Cycle 7(7):870-3

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Abstract


A prerequisite of calcium signaling is the maintenance of cytoplasmic free Ca(2+) within a narrow, sub-micromolar range, compatible with cell viability. A variety of stress inducing agents and drugs can lead to a disruption of calcium homeostasis with ensuing toxicity. Amiodarone, an anti-arrhythmic drug with broad range microbicidal effect, has been shown to trigger a calcium burst in the yeast Saccharomyces cerevisiae. Recently, we reported that amiodarone elicits a starvation response, blocks cell cycle progression at multiple stages and represses the transcription of cell cycle genes. Here, we examine the connections between Ca(2+)-calcineurin signaling, nutrient sensing and regulation of the cell cycle.

Reference Type
Journal Article | Review | Research Support, N.I.H., Extramural
Authors
Zhang YQ, Rao R
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