Reference: Caplan AJ, et al. (2007) Multiple kinases and system robustness: a link between Cdc37 and genome integrity. Cell Cycle 6(24):3145-7

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Abstract

We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.

Reference Type
Letter | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Extramural
Authors
Caplan AJ, Ma'ayan A, Willis IM
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Interaction Annotations

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Interactor Interactor Type Assay Annotation Action Modification Phenotype Source Reference

Gene Ontology Annotations

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Gene Gene Ontology Term Qualifier Aspect Method Evidence Source Assigned On Annotation Extension Reference

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Gene Phenotype Experiment Type Mutant Information Strain Background Chemical Details Reference

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Regulator Target Experiment Assay Construct Conditions Strain Background Reference