Reference: Ulrich HD (2007) PCNA(SUMO) and Srs2: a model SUMO substrate-effector pair. Biochem Soc Trans 35(Pt 6):1385-8

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Abstract


Attachment of the SUMO (small ubiquitin-related modifier) to the replication factor PCNA (proliferating-cell nuclear antigen) in the budding yeast has been shown to recruit a helicase, Srs2, to active replication forks, which in turn prevents unscheduled recombination events. In the present review, I will discuss how the interaction between SUMOylated PCNA and Srs2 serves as an example for a mechanism by which SUMO modulates the properties of its targets and mediates the activation of downstream effector proteins.

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Journal Article
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Ulrich HD
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