Reference: Tamaki H (2007) Glucose-stimulated cAMP-protein kinase a pathway in yeast Saccharomyces cerevisiae. J Biosci Bioeng 104(4):245-50

Reference Help

Abstract

In the yeast Saccharomyces cerevisiae, glucose signals activate the production of cellular cAMP. This signaling pathway is called the cAMP-protein kinase A (PKA) pathway, which plays a major role in the regulation of cell growth, metabolism, and stress resistance. Extensive studies have been carried out to clarify the mechanism of this pathway, and many factors involved in the pathway have been identified such as small G proteins, the GDP-GTP exchange factor, adenylate cyclase, and PKA. Also, additional elements involved in this pathway have been evaluated in the last decade. A heterotrimeric G protein alpha subunit was identified as a mammalian Galpha homologue, and a G-protein-coupled receptor (GPCR), which initiates the signaling pathway in response to glucose addition, was identified. GPCR-Galpha was shown to function in a signaling pathway that acts parallel to small G proteins. These signaling pathways regulate cell growth and differentiation in response to nutrients.

Reference Type
Journal Article
Authors
Tamaki H
Primary Lit For
Additional Lit For
Review For

Interaction Annotations

Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.

Interactor Interactor Type Assay Annotation Action Modification Phenotype Source Reference

Gene Ontology Annotations

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene Gene Ontology Term Qualifier Aspect Method Evidence Source Assigned On Annotation Extension Reference

Phenotype Annotations

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

Gene Phenotype Experiment Type Mutant Information Strain Background Chemical Details Reference

Regulation Annotations

Increase the total number of rows displayed on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; to filter the table by a specific experiment type, type a keyword into the Filter box (for example, “microarray”); download this table as a .txt file using the Download button or click Analyze to further view and analyze the list of target genes using GO Term Finder, GO Slim Mapper, SPELL, or YeastMine.

Regulator Target Experiment Assay Construct Conditions Strain Background Reference