Reference: Tu BP, et al. (2007) Cyclic changes in metabolic state during the life of a yeast cell. Proc Natl Acad Sci U S A 104(43):16886-91

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Abstract


Budding yeast undergo robust oscillations in oxygen consumption during continuous growth in a nutrient-limited environment. Using liquid chromatography-mass spectrometry and comprehensive 2D gas chromatography-mass spectrometry-based metabolite profiling methods, we have determined that the intracellular concentrations of many metabolites change periodically as a function of these metabolic cycles. These results reveal the logic of cellular metabolism during different phases of the life of a yeast cell. They may further indicate that oscillation in the abundance of key metabolites might help control the temporal regulation of cellular processes and the establishment of a cycle. Such oscillations in metabolic state might occur during the course of other biological cycles.

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Journal Article
Authors
Tu BP, Mohler RE, Liu JC, Dombek KM, Young ET, Synovec RE, McKnight SL
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