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Reference: Zemp I and Kutay U (2007) Nuclear export and cytoplasmic maturation of ribosomal subunits. FEBS Lett 581(15):2783-93

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Abstract

Based on the characterization of ribosome precursor particles and associated trans-acting factors, a biogenesis pathway for the 40S and 60S subunits has emerged. After nuclear synthesis and assembly steps, pre-ribosomal subunits are exported through the nuclear pore complex in a Crm1- and RanGTP-dependent manner. Subsequent cytoplasmic biogenesis steps of pre-60S particles include the facilitated release of several non-ribosomal proteins, yielding fully functional 60S subunits. Cytoplasmic maturation of 40S subunit precursors includes rRNA dimethylation and pre-rRNA cleavage, allowing 40S subunits to achieve translation competence. We review current knowledge of nuclear export and cytoplasmic maturation of ribosomal subunits.

Reference Type
Journal Article | Review | Research Support, Non-U.S. Gov't
Authors
Zemp I, Kutay U
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