Reference: Fox CA and McConnell KH (2005) Toward biochemical understanding of a transcriptionally silenced chromosomal domain in Saccharomyces cerevisiae. J Biol Chem 280(10):8629-32

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Abstract


Silencing of the HMR domain in Saccharomyces cerevisiae requires the action of a DNA element called a silencer that binds sequence-specific DNA binding proteins to form a silencer-protein complex (SPC). The SPC recruits specialized chromatin proteins, the Sir proteins that deacetylate and bind nucleosomes within HMR. Sir-dependent chromatin is absolutely necessary to repress transcription of a gene within HMR and causes repression at a step after recruitment of the RNA Pol II holoenzyme. Specific mechanisms that include specialized nucleosomes help confine Sir-dependent chromatin to HMR.

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Journal Article
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Fox CA, McConnell KH
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