Reference: Bork P, et al. (2004) Protein interaction networks from yeast to human. Curr Opin Struct Biol 14(3):292-9

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Abstract

Protein interaction networks summarize large amounts of protein-protein interaction data, both from individual, small-scale experiments and from automated high-throughput screens. The past year has seen a flood of new experimental data, especially on metazoans, as well as an increasing number of analyses designed to reveal aspects of network topology, modularity and evolution. As only minimal progress has been made in mapping the human proteome using high-throughput screens, the transfer of interaction information within and across species has become increasingly important. With more and more heterogeneous raw data becoming available, proper data integration and quality control have become essential for reliable protein network reconstruction, and will be especially important for reconstructing the human protein interaction network.

Reference Type
Journal Article | Review | Comparative Study
Authors
Bork P, Jensen LJ, von Mering C, Ramani AK, Lee I, Marcotte EM
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Interaction Annotations

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Interactor Interactor Type Assay Annotation Action Modification Phenotype Source Reference

Gene Ontology Annotations

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Gene Gene Ontology Term Qualifier Aspect Method Evidence Source Assigned On Annotation Extension Reference

Phenotype Annotations

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Gene Phenotype Experiment Type Mutant Information Strain Background Chemical Details Reference

Regulation Annotations

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Regulator Target Experiment Assay Construct Conditions Strain Background Reference