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Reference: Longo VD and Finch CE (2003) Evolutionary medicine: from dwarf model systems to healthy centenarians? Science 299(5611):1342-6

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Abstract


Restriction of the number of calories consumed extends longevity in many organisms. In rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation without irreversible side effects. In organisms ranging from yeast to mice, mutations in glucose or IGF-I-like signaling pathways extend life-span but also cause glycogen or fat accumulation and dwarfism. This information suggests a new category of drugs that could prevent or postpone diseases of aging with few adverse effects.

Reference Type
Journal Article | Review | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S.
Authors
Longo VD, Finch CE
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