Reference: Endo S, et al. (2003) Identification of human dehydrodolichyl diphosphate synthase gene. Biochim Biophys Acta 1625(3):291-5

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Abstract


We isolated a cDNA encoding human dehydrodolichyl diphosphate (Dedol-PP) synthase and expressed the gene in a yeast mutant strain SNH23-7D, which is deficient in Dedol-PP synthase activity. The identity of the cloned enzyme was confirmed by functional complementation of SNH23-7D strain together with in vitro Dedol-PP synthase activity assay. Northern blot analysis indicated that testis and kidney expressed Dedol-PP synthase mRNA at high levels.

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Journal Article
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Endo S, Zhang YW, Takahashi S, Koyama T
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