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Reference: Martini E and Keeney S (2002) Sex and the single (double-strand) break. Mol Cell 9(4):700-2

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Abstract

It has been known for some time that DNA double-strand breaks (DSBs) initiate homologous recombination during meiosis. Two recent studies show that the fate of a single DSB in yeast is strongly influenced by the presence of other breaks in the genome, hinting that cell-wide or chromosome-regional mechanisms control the outcome of DSB repair.

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Martini E, Keeney S
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