Reference: Manon S, et al. (2001) Mitochondrial AAA-type protease Yme1p is involved in Bax effects on cytochrome c oxidase. Biochem Biophys Res Commun 289(5):1314-9

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Abstract


Expression of the pro-apoptotic protein Bax in yeast Saccharomyces cerevisiae induces a release of cytochrome c accompanied by a decrease of the amount of cytochrome c oxidase. Here we show that the decrease of cytochrome c oxidase is due to the activation of mitochondrial protease Yme1p, of which cytochrome c oxidase subunit 2 (Cox2p) is a substrate. The absence of Yme1p slightly delays Bax-induced cell death, suggesting a role of this protease in yeast cell death and thus of its mammalian homologue in apoptosis. (c)2001 Elsevier Science.

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Journal Article
Authors
Manon S, Priault M, Camougrand N
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