Reference: Cross GG, et al. (2001) Immunostimulant oxidized beta-glucan conjugates. Int Immunopharmacol 1(3):539-50

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Abstract


beta-Glucans are polysaccharides that act as nonspecific immune system stimulants. However, many beta-Glucans are sparingly soluble in water. This work describes an oxidative procedure, which solubilizes the beta-Glucan from Saccharomyces cerevisiae and maintains its immunostimulatory properties. Furthermore, the carboxylates at the site of oxidation allow for the conjugation of small molecule immunostimulants. Both the parent oxidized beta-glucan and its conjugates with O-beta-alanyl-5-[6-(N,N'-dimethylamino)purin-9-yl]pentanol stimulate cytotoxic T-lymphocytes (CTLs), B cells and macrophages. In addition, they both stimulate natural killer (NK) cells, a property which the small molecule purine does not possess.

Reference Type
Journal Article | In Vitro
Authors
Cross GG, Jennings HJ, Whitfield DM, Penney CL, Zacharie B, Gagnon L
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