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Reference: Mitchell P and Tollervey D (2001) mRNA turnover. Curr Opin Cell Biol 13(3):320-5

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Abstract


Nuclear RNA-binding proteins can record pre-mRNA processing events in the structure of messenger ribonucleoprotein particles (mRNPs). During initial rounds of translation, the mature mRNP structure is established and is monitored by mRNA surveillance systems. Competition for the cap structure links translation and subsequent mRNA degradation, which may also involve multiple deadenylases.

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Journal Article | Review
Authors
Mitchell P, Tollervey D
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