Reference: Gregory PD, et al. (2001) Histone acetylation and chromatin remodeling. Exp Cell Res 265(2):195-202

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Abstract

Chromatin represents a repressive barrier to the process of transcription. This molecular obstacle is a highly dynamic structure, able to compact the DNA of the entire genome into the confines of a nucleus, and yet it allows access to the genetic information held within. The acetylation of histones has emerged as a regulatory mechanism capable of modulating the properties of chromatin and thus the competence of the DNA template for transcriptional activation. The role of acetylation in chromatin remodeling is therefore of paramount importance to our understanding of gene regulation in vivo.CI - Copyright 2001 Academic Press.

Reference Type
Journal Article | Review | Research Support, Non-U.S. Gov't
Authors
Gregory PD, Wagner K, Horz W
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