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Reference: Wassmann K and Benezra R (2001) Mitotic checkpoints: from yeast to cancer. Curr Opin Genet Dev 11(1):83-90

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Abstract

Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.

Reference Type
Journal Article | Review | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S.
Authors
Wassmann K, Benezra R
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