Reference: Pidoux AL and Allshire RC (2000) Centromeres: getting a grip of chromosomes. Curr Opin Cell Biol 12(3):308-19

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Abstract


On monocentric chromosomes the centromere is the chromosomal site at which the kinetochore complex is assembled. This complex mediates the attachment and movement of chromosomes along spindle microtubules. The centromere is usually the last site to retain cohesion between sister centromeres. The location of the main sensor for defective spindle assembly at the kinetochore allows the release of this cohesion, and thus progression through mitosis, to be held in check until key events have been completed. The intricate nature of the centromere-kinetochore complexes and the events they co-ordinate and react to is presently being dissected by studies in several organisms. In particular, several new kinetochore proteins have been identified in many organisms over the last year.

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Journal Article | Review | Research Support, Non-U.S. Gov't
Authors
Pidoux AL, Allshire RC
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