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Jelinsky SA and Samson LD  (1999) Global response of Saccharomyces cerevisiae to an alkylating agent. Proc Natl Acad Sci U S A 96(4):1486-91

Abstract: DNA chip technology enables simultaneous examination of how approximately 6,200 Saccharomyces cerevisiae gene transcript levels, representing the entire genome, respond to environmental change. By using chips bearing oligonucleotide arrays, we show that, after exposure to the alkylating agent methyl methanesulfonate, approximately 325 gene transcript levels are increased and approximately 76 are decreased. Of the 21 genes that already were known to be induced by a DNA-damaging agent, 18 can be scored as inducible in this data set, and surprisingly, most of the newly identified inducible genes are induced even more strongly than these 18. We examined 42 responsive and 8 nonresponsive ORFs by conventional Northern blotting, and 48 of these 50 ORFs responded as they did by DNA chip analysis, with magnitudes displaying a correlation coefficient of 0.79. Responsive genes fall into several expected and many unexpected categories. Evidence for the induction of a program to eliminate and replace alkylated proteins is presented.

Status: Published Type: Journal Article PubMed ID: 9990050

Topics addressed in this paper

Number of different genes curated to this paper: 139

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AAD14 AAD16 AAD4 AAD6 ABF1 ADP1 AGX1 AMD2 APE1 ARG1
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Topics Genes linked to topics (#11 - 20 )
ARG3 ARG4 ARG5,6 ARG7 ARO1 ARO3 ARO9 ASP3-1 ASP3-3 ASP3-4
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Topics Genes linked to topics (#21 - 30 )
ATR1 AYT1 BDH1 BNA1 BNA3 CCT8 CDC53 CHS6 COY1 CPA2
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Topics Genes linked to topics (#31 - 40 )
CRM1 CTK3 DAK1 DDI1 DDI2 DDI3 DNM1 ECM29 ECM38 ECM4
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Topics Genes linked to topics (#41 - 50 )
FLR1 FOX2 FRE1 FRM2 FZF1 GCV1 GCV2 GCY1 GDB1 GDH2
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Topics Genes linked to topics (#51 - 60 )
GSP2 GTT1 GTT2 HER1 HIS5 HOM3 HOS2 IDP1 IRC24 IRC7
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Topics Genes linked to topics (#61 - 70 )
ISU2 KNS1 LAG2 LAS17 LEU4 LHS1 LSC2 LYS1 MAS1 MCH4
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Topics Genes linked to topics (#71 - 80 )
MET10 MTF1 MVP1 NAB2 NCE103 NIT1 NPL4 NPR1 NSP1 NTG1
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Topics Genes linked to topics (#81 - 90 )
NTH1 ORT1 OXP1 OYE3 PAI3 PCL5 PDR10 PEP5 PKH2 PRE3
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Topics Genes linked to topics (#91 - 100 )
PRI1 PRX1 PUT2 PYC1 RFA1 RIB1 RIB5 RPN1 RRD2 RTK1
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Topics Genes linked to topics (#101 - 110 )
SAM37 SHH4 SNU114 SNZ1 SRY1 SSA1 SSU1 STE11 STR2 TAP42
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Topics Genes linked to topics (#111 - 120 )
TFS1 TIS11 TPK1 TPN1 TRP2 TRP3 TRP4 TWF1 UBC13 UBC5
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Topics Genes linked to topics (#121 - 130 )
UBI4 UBP15 UBP2 UBP6 VPS35 VPS5 VPS73 YAP1 YCR029C YHB1
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Topics Genes linked to topics (#131 - 139 )
YJL068C YLL058W YML131W YPL150W YRR1 YSC84 YTP1 ZTA1 ZWF1
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