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Patton EE, et al.  (1998) Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet 14(6):236-43

Abstract: The ubiquitin-dependent proteolytic pathway targets many key regulatory proteins for rapid intracellular degradation. Specificity in protein ubiquitination derives from E3 ubiquitin protein ligases, which recognize substrate proteins. Recently, analysis of the E3s that regulate cell division has revealed common themes in structure and function. One particularly versatile class of E3s, referred to as Skp1p-Cdc53p-F-box protein (SCF) complexes, utilizes substrate-specific adaptor subunits called F-box proteins to recruit various substrates to a core ubiquitination complex. A vast array of F-box proteins have been revealed by genome sequencing projects, and the early returns from genetic analysis in several organisms promise that F-box proteins will participate in the regulation of many processes, including cell division, transcription, signal transduction and development.

Status: Published Type: Journal Article | Review | Review, Tutorial PubMed ID: 9635407

Topics addressed in this paper

Number of different genes curated to this paper: 34

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Topics Genes linked to topics (#1 - 10 )
APC2 CBF2 CDC34 CDC4 CDC53 CDC6 CDH1 CEP3 CLN1 CLN2
Alias blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball
Protein Sequence Features blue ball
Regulation of blue ball blue ball blue ball blue ball
Regulatory Role blue ball blue ball blue ball blue ball blue ball blue ball
Reviews blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
CLN3 COS111 CTF13 DAS1 DIA2 ELA1 FAR1 GCN4 GIC1 GIC2
Additional Literature blue ball
Function/Process blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball blue ball blue ball
Reviews blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
GRR1 HRT3 HXT1 MDM30 MET30 MFB1 RCY1 SIC1 SKP1 SKP2
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball
Regulatory Role blue ball blue ball blue ball
Reviews blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 34 )
UFO1 YDR131C YDR306C YLR224W
Function/Process blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball

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