Nelms BE, et al. (1998) In situ visualization of DNA double-strand break repair in human fibroblasts. Science 280(5363):590-2
Abstract: A method was developed to examine DNA repair within the intact cell. Ultrasoft x-rays were used to induce DNA double-strand breaks (DSBs) in defined subnuclear volumes of human fibroblasts and DNA repair was visualized at those sites. The DSBs remained in a fixed position during the initial stages of DNA repair, and the DSB repair protein hMre11 migrated to the sites of damage within 30 minutes. In contrast, hRad51, a human RecA homolog, did not localize at sites of DNA damage, a finding consistent with the distinct roles of these proteins in DNA repair.
|Status: Published||Type: Journal Article||PubMed ID: 9554850|
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