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Zachariae W, et al.  (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9

Abstract: Entry into anaphase and exit from mitosis depend on a ubiquitin-protein ligase complex called the anaphase-promoting complex (APC) or cyclosome. At least 12 different subunits were detected in the purified particle from budding yeast, including the previously identified proteins Apc1p, Cdc16p, Cdc23p, Cdc26p, and Cdc27p. Five additional subunits purified in low nanogram amounts were identified by tandem mass spectrometric sequencing. Apc2p, Apc5p, and the RING-finger protein Apc11p are conserved from yeast to humans. Apc2p is similar to the cullin Cdc53p, which is a subunit of the ubiquitin-protein ligase complex SCFCdc4 required for the initiation of DNA replication.

Status: Published Type: Journal Article PubMed ID: 9469814

Topics addressed in this paper

Number of different genes curated to this paper: 14

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Topics Genes linked to topics (#1 - 10 )
APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27
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Topics Genes linked to topics (#11 - 14 )
CDC34 CDC4 CDC53 DOC1
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Archived Literature blue ball
Fungal Related Genes/Proteins blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball
Protein Physical Properties blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball
Techniques and Reagents blue ball blue ball blue ball

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