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Ganot P, et al.  (1997) Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs. Cell 89(5):799-809

Abstract: During the nucleolar maturation of eukaryotic ribosomal RNAs, many selected uridines are converted into pseudouridine by a thus far undefined mechanism. The nucleolus contains a large number of small RNAs (snoRNAs) that share two conserved sequence elements, box H and ACA. In this study, we demonstrate that site-specific pseudouridylation of rRNAs relies on short ribosomal signal sequences that are complementary to sequences in box H/ACA snoRNAs. Genetic depletion and reconstitution studies on yeast snR5 and snR36 snoRNAs demonstrate that box H/ACA snoRNAs function as guide RNAs in rRNA pseudouridylation. These results define a novel function for snoRNAs and further reinforce the idea that base pairing is the most common way to obtain specific substrate-"enzyme" interactions during rRNA maturation.

Status: Published Type: Journal Article PubMed ID: 9182768

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
CBF5 GAR1 NHP2 NOP10 SNR11 SNR189 SNR3 SNR31 SNR32 SNR33
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
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Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball
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Substrates/Ligands/Cofactors blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
SNR34 SNR35 SNR36 SNR37 SNR42 SNR43 SNR44 SNR46 SNR49 SNR5
Additional Literature blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball
Other Features blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball
Strains/Constructs blue ball blue ball

Topics Genes linked to topics (#21 - 22 )
SNR8 SNR9
Additional Literature blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball
Function/Process blue ball
Other Features blue ball

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