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el Moualij B, et al.  (1997) Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae. Yeast 13(6):573-81

Abstract: The screening of the open reading frames identified in the whole yeast genome has allowed us to discover 34 proteins belonging to the mitochondrial carrier family. By phylogenetic study, they can be divided into 27 subfamilies including ADP/ATP, phosphate and citrate carriers, putative oxoglutarate and GDC carriers and 22 new subfamilies. Topology predictions using the 'positive inside rule' approach have shown that the yeast carriers are similarly oriented with both extremities exposed to the cytosol. In each subfamily, a strict conservation of the charged residues in the six transmembrane alpha-helices is observed, suggesting a functional role for these residues and the existence of 27 functionally distinct carriers.

Status: Published Type: Journal Article PubMed ID: 9178508

Topics addressed in this paper

Number of different genes curated to this paper: 34

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Topics Genes linked to topics (#1 - 10 )
AAC1 AAC3 AGC1 ANT1 CRC1 CTP1 DIC1 FLX1 GGC1 LEU5
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MIR1 MRS3 MRS4 MTM1 OAC1 ODC1 ODC2 ORT1 PET8 PET9
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Topics Genes linked to topics (#21 - 30 )
PIC2 RIM2 SAL1 SFC1 TPC1 YDL119C YEA6 YFR045W YHM2 YIA6
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Topics Genes linked to topics (#31 - 34 )
YMC1 YMC2 YMR166C YPR011C
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