Varshavsky A (1997) The N-end rule pathway of protein degradation. Genes Cells 2(1):13-28
Abstract: The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. Ubiquitin is a 76-residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of the N-end rule pathway.
|Status: Published||Type: Journal Article | Review | Review, Tutorial||PubMed ID: 9112437|
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