Noel JP, et al. (1993) The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature 366(6456):654-63
Abstract: The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic studies, suggests: how an activated receptor might open this cleft to allow nucleotide exchange; a mechanism for GTP-induced changes in effector and receptor binding surfaces; and a mechanism for GTPase activity not evident from previous data.
|Status: Published||Type: Journal Article||PubMed ID: 8259210|